Sunday, September 21, 2014

Children's Oncology Group Fall Meeting

This meeting was productive.  Our lab presented at the Soft Tissue Sarcoma Chemotherapy Breakout session on "Three novel target-therapy pairs for potential clinical trials within 18 months?", as well as at the CNS session on "Ad Hoc Preclinical Consortia to Support Trial Design".  Both presentations bridged scientific/drug discovery and the potential initiation of clinical trials.    

Tuesday, September 16, 2014

Cold Spring Harbor Laboratory

We are grateful to collaborator Chris Vakoc for the opportunity to present the lecture, "Rhabdomyosarcoma:  Developmental Origins & Therapeutic Opportunities" as the prelude to a collaboration made possible by generous rhabdomyosarcoma patient advocates in this community.  

Monday, September 1, 2014

Save the Date: Rhabdomyosarcoma & Soft Tissue Sarcoma Conference

The Pablove Foundation is hosting a scientific conference on rhabdomyosarcoma & soft tissue sarcoma November 6-8, 2014 in Los Angeles.  This is a by-invitation meeting for clinician-scientists and researchers from the US and abroad; however, the symposium on Saturday November 8 will be open to the public.  Registration information will likely be available late Summer/early Fall through the Pablove Foundation website.  
  
update:  the website is now open for registration.  

Tuesday, August 12, 2014

Muscle Differentiation as Rhabdomyosarcoma Therapy

Matthew from our lab wrote this commentary in Cancer Cell, which frames the question of how soon myo-differentiation therapy will be feasible for childhood muscle cancer.  The commentary discusses the article here.  Graphic illustration by Nick Escobar. 

Wednesday, July 23, 2014

a tool for innovation

video
We are grateful to the Alex' Lemonade Stand Foundation for our new instrument, a Form1 3D printer. With this device we can generate custom tissue culture incubation chambers. This project is pioneered by Kirsten and Richard this Summer.  stay tuned!

Wednesday, July 16, 2014

congratulations, Jinu!

[07/14/14]  The article, Lineage of origin in rhabdomyosarcoma informs pharmacological response, is now available here.  
   
[06/03/14]  Congratulations to Jinu whose paper was recently accepted for publication to Genes & Development.  This work was funded in part by NIH as well as the Scott Carter Foundation.  Clinical translation is hopefully possible, and thus additional preclinical studies with cooperative group and pharmaceutical partners are in discussion.  We are grateful to all our collaborators, especially Atiya Mansoor (OHSU), Joel Michalek and Ben Ehler and Monica Suelves (IMPPC).  

Wednesday, July 9, 2014

Welcoming Kirsten

We are excited to have Kirsten on our team this Summer.  Kirsten is an orthopedic surgery resident with a keen interest in tissue engineering.  


" I graduated from the University of Missouri–Kansas City School of Medicine in 2011 with my MD and BA in Biology through the combined MD/BA program.  Shortly, thereafter I moved to Portland to start my 5 years of residency training in Orthopaedic Surgery at OHSU.  My interests in the field include joint reconstruction and orthopaedic oncology.   I hope to bring the unique perspective of a surgeon scientist to Dr. Keller's lab as we work to develop a 3D in vitro sarcoma model system.  In my free time I enjoy playing disc golf and spoiling my cats.  Kirsten "